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GENERIC AND SELECTED BRAND NAME DRUG DATA (samples of over 1400 listed)
Abacavir (Ziagen) WARNING: Allergy (fever, rash, fatigue, GI, resp) reported; stop drug immediately & do not rechallenge; lactic acidosis & hepatomegaly/steatosis reported Uses: *HIV Infxn* Action: NRTI Dose: Adults. 300 mg PO bid or 600 mg PO daily Peds. 8 mg/kg bid Caution: [C, –] CDC recommends HIV-infected mothers not breast-feed (transmission risk) Disp: Tabs 300 mg; soln 20 mg/mL SE: See Warning, ↑ LFTs, fat redistribution Notes: Numerous drug interactions.
Abatacept (Orencia) Uses:* Mod/severe RA w/inadequate response to one or more DMARDs Action: Selective costimulation modulator, ↓ T-cell activation Dose: Initial 500 mg (<60 kg="" 750="" mg="" 60="" 100="" 1="" gm="">100kg) IV over 30 min; repeat at 2 and 4 wk, then every 4 wk Caution: w/TNF blockers[C; ?/-] COPD; h/o recurrent/localized/chronic, /predisposition to Infxn Contra: w/TNF antagonists (Increase Infxn); w/live vaccines w/in 3 mo of D/C abatacept Disp: IV powder: 250 mg/10 mL SE: HA, URI, N, nasopharyngitis, Infxn, malignancy, inf Rxns/hypersensitivity (dizziness, HA, HTN), COPD exacerbations, cough,dyspnea Notes: Screen for TB prior to use
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